Developmental Regulation of Genomic Imprinting of the IGF2 Gene in Human Liver1
نویسنده
چکیده
of the germ lines. Previous data have suggested that in nonmalignant tissues an imprint is constant throughout life and is not susceptible to modification, except during gametogenesis. The present study examines allelic expression of the IGF2 gene in human liver during postnatal development. The data show that the IGF2 gene is imprinted (i.e., monoallelically expressed) in liver at the age of 6 months, but at the age of 8—10months imprinting is relaxed and expression of the IGF2 gene is clearly biallelic by the second year of life, indicating the presence of a tissue-specific activity that can modify genomic imprinting.
منابع مشابه
I-50: Embryo Loss Due to Epigenetic Anomaliesin the Male Germ Line: Role of Estrogen
Background: To investigate if aberrant methylation and expression of imprinted genes of the Igf2-H19 locus in the spermatozoa and embryos could be a paternal epigenetic factor involved in early embryo loss To elucidate the role of estrogen in acquisition of the imprinting at the Igf2-H19 locus during spermatogenesis Materials and Methods: Adult male rats of Holtzman strain were administered tam...
متن کاملGenomic imprinting and carcinogenesis.
The Mendelian inheritance is based on the fundamental rule in which mammalian genes are expressed equally from two homologous biparental alleles. Recently a small number of genes have been identified to show an exception to this rule in that homologous alleles can function differently in somatic cells depending on whether they come from the mother or the father. This intriguing biological pheno...
متن کاملImprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith-Wiedemann syndrome.
Genomic imprinting is a novel form of control of gene expression in which the transcription of each allele of an imprinted gene is dependent on the sex of the gamete from which it was derived; to date > 15 genes have been demonstrated to show imprinting. The maintenance of a normal imprinting pattern in many loci has been shown to be essential for normal development and adult life. Many tumours...
متن کاملO-11: N-a-acetyltransferase 10 Protein Regulates DNA Methylation and Embryonic Development
Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
متن کاملMultiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
Genomic imprinting is an epigenetic process that results in the preferential silencing of one of the two parental copies of a gene. Although the precise mechanisms by which genomic imprinting occurs are unknown, the tendency of imprinted genes to exist in chromosomal clusters suggests long-range regulation through shared regulatory elements. We characterize a 800-kb region on the distal end of ...
متن کامل